Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection
Identifieur interne : 000F99 ( Main/Exploration ); précédent : 000F98; suivant : 001000Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection
Auteurs : Eu Suk Kim ; Pyoeng Gyun Choe ; Wan Beom Park ; Hong Sang Oh ; Eun Jung Kim ; Eun Young Nam ; Sun Hee Na ; Moonsuk Kim ; Kyoung-Ho Song ; Ji Hwan Bang ; Sang Won Park ; Hong Bin Kim ; Nam Joong Kim ; Myoung-Don OhSource :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2016.
Abstract
Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/µL,
Url:
DOI: 10.3346/jkms.2016.31.11.1717
PubMed: 27709848
PubMed Central: 5056202
Affiliations:
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Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection</title><author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Oh, Hong Sang" sort="Oh, Hong Sang" uniqKey="Oh H" first="Hong Sang" last="Oh">Hong Sang Oh</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Kim, Eun Jung" sort="Kim, Eun Jung" uniqKey="Kim E" first="Eun Jung" last="Kim">Eun Jung Kim</name></author><author><name sortKey="Nam, Eun Young" sort="Nam, Eun Young" uniqKey="Nam E" first="Eun Young" last="Nam">Eun Young Nam</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Na, Sun Hee" sort="Na, Sun Hee" uniqKey="Na S" first="Sun Hee" last="Na">Sun Hee Na</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Kim, Moonsuk" sort="Kim, Moonsuk" uniqKey="Kim M" first="Moonsuk" last="Kim">Moonsuk Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Korean Medical Science</title><idno type="ISSN">1011-8934</idno><idno type="eISSN">1598-6357</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around day 7 of illness, and dyspnea developed at the end of the first week and became apparent in the second week. Median time from symptom onset to oxygen supplementation was 8 days. The severe group had higher neutrophil counts during week 1 than the mild group (4,500 vs. 2,200/µL, <italic>P</italic> = 0.026). In the second week of illness, the severe group had higher serum levels of IL-6 (54 vs. 4 pg/mL, <italic>P</italic> = 0.006) and CXCL-10 (2,642 vs. 382 pg/mL, <italic>P</italic> < 0.001). IFN-α response was not observed in mild cases. Our data shows that clinical condition may suddenly deteriorate around 7 days of illness and the serum levels of IL-6 and CXCL-10 was significantly elevated in MERS-CoV patients who developed severe diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Oh, Md" uniqKey="Oh M">MD 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Lee</name></author><author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Lun, Sw" uniqKey="Lun S">SW Lun</name></author><author><name sortKey="Lui, G" uniqKey="Lui G">G Lui</name></author><author><name sortKey="Wong, B" uniqKey="Wong B">B Wong</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Lam, Cw" uniqKey="Lam C">CW Lam</name></author><author><name sortKey="Cockram, Cs" uniqKey="Cockram C">CS Cockram</name></author><author><name sortKey="Choi, Kw" uniqKey="Choi K">KW Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name></author><author><name sortKey="Wong, Ry" uniqKey="Wong R">RY Wong</name></author><author><name sortKey="Lun, Sw" uniqKey="Lun S">SW Lun</name></author><author><name sortKey="Ngai, Kl" uniqKey="Ngai K">KL Ngai</name></author><author><name sortKey="Lui, Gc" uniqKey="Lui G">GC Lui</name></author><author><name sortKey="Wong, Bc" uniqKey="Wong B">BC Wong</name></author><author><name sortKey="Lee, Sk" uniqKey="Lee S">SK Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chi, Y" uniqKey="Chi Y">Y Chi</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Wen, T" uniqKey="Wen T">T Wen</name></author><author><name sortKey="Cui, L" uniqKey="Cui L">L Cui</name></author><author><name sortKey="Ge, Y" uniqKey="Ge Y">Y Ge</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name></author><author><name sortKey="Ge, A" 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uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name></author><author><name sortKey="Brining, Dl" uniqKey="Brining D">DL Brining</name></author><author><name sortKey="Fischer, Er" uniqKey="Fischer E">ER Fischer</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name></author><author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name><name sortKey="Kim, Eun Jung" sort="Kim, Eun Jung" uniqKey="Kim E" first="Eun Jung" last="Kim">Eun Jung Kim</name><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name><name sortKey="Kim, Moonsuk" sort="Kim, Moonsuk" uniqKey="Kim M" first="Moonsuk" last="Kim">Moonsuk Kim</name><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name><name sortKey="Na, Sun Hee" sort="Na, Sun Hee" uniqKey="Na S" first="Sun Hee" last="Na">Sun Hee Na</name><name sortKey="Nam, Eun Young" sort="Nam, Eun Young" uniqKey="Nam E" first="Eun Young" last="Nam">Eun Young Nam</name><name sortKey="Oh, Hong Sang" sort="Oh, Hong Sang" uniqKey="Oh H" first="Hong Sang" last="Oh">Hong Sang Oh</name><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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